Endocrine Abstracts

Although insulinoma commonly presents as fasting hypoglycaemia it can rarely present as post prandial hypoglycaemia and even less rarely in association with Type 2 Diabetes Mellitus (T2DM). We describe a case of insulinoma presenting as post-prandial hypoglycaemia and T2DM.A 60 year old man presented with a 6 year history of episodes of double vision and loss of concentration occurring post-prandially. His symptoms were associated with capillary blood gl...

Background: Thyrotoxicosis can present as heart failure, especially in elderly patients. We report a case of thyrotoxicosis causing reversible right-sided heart failure.Case: A 75-year-old Caucasian lady presented with a month’s history of shortness of breath, abdominal distension and ankle oedema. She complained of hot sweats with palpitations, On admission, she was thyrotoxic with evidence of severe right sided heartfailure.Her ECG showed fast atr...

Background: Premature ovarian failure is not uncommon in patients with polyglandular autoimmune conditions. It is rare for patients to become pregnant beyond the menopause. We present a patient with premature ovarian failure who spontaneously conceived after attaining menopausal state.Case: We had a 41-year-old Asian lady with type1 diabetes mellitus since 30 years of age. She had widespread vitiligo, strongly positive thyroid microsomal antibody and a f...

We had a 29 year old lady with 11 years history of hirsutism and amenorrhoea. She was diagnosed as polycystic ovarian syndrome in a different hospital few years ago and commenced on metformin and spironolactone. She noticed worsening of hirsuitism over last year, needing to shave daily, along with loss scalp hair, deepening of voice and clitoromegaly. On examination, she was obese without any overt signs of Cushing’s syndrome. She had severe hirsuitism affecting face, arm...

We had a 67-year-old lady who presented with 2-week history of shortness of breath and dry cough. Her past medical history includes dense left sided hemiplegia from previous stroke, hemiarthroplasty for fracture neck of femur, hypertension and osteoporosis. She had a large goitre for many years without any recent change in size of the goitre and there was no history of dysphagia. She had a large goitre with engorged neck veins, but no palpable lymph nodes. Her Chest X-ray show...

Introduction: BTA guidelines-2014 outlined the need for key features to be included in thyroid ultrasound scan (USS) reporting including risk stratification. The aim of this audit was to evaluate the quality of thyroid-USS reporting at Northumbria Healthcare NHS Foundation Trust (NHCT); using BTA guidelines as the gold standard.Methods: All thyroid/neck-USS between 1st November to 31st December 2015 were retrieved from radiology records at NHCT. Scans ev...

Introduction and aim: Primary hyperparathyroidism is the commonest cause of hypercalcaemia in out patient population. Primary hyperparathyroidism has become relatively common over the recent years as calcium levels are routinely evaluated since the introduction of multichannel analysers worldwide. Our aim was to audit the use and role of preoperative imaging (Ultrasound and Sestamibi scan) in localising parathyroid adenoma.Methods: We reviewed case notes...

Background: The aim of radioiodine treatment is to ameliorate hyperthyroidism, with minimal risk of hypothyroidism. The Royal College of Physicians recommends the administration of 400–550 Mbq for Grave’s disease and 550–600 Mbq for toxic multinodular goitre.Aim: Our audit aimed to analyze the results of our current practice of radioiodine treatment, and also to compare it with the published results of success rate and hypothyroidism.<...

Introduction: The association between fatigue, functional status and subclinical hypothyroidism (SCH) remains unclear. The available data is not consistent, and this is likely to be due to selection bias in studies recruiting patients from clinic rather than unselected community populations. Only population surveys looking at prevalence of fatigue and functional status in SCH are likely to provide the answer.Objective and Methodology: We compared the pre...

Background: It is well established that subclinical hypothyroidism (SCH) is associated with mild ventricular dysfunction and early cardiovascular disease (CVD), but it is unknown if there is an underlying defect in cardiac bio-energetic function.Objective: To quantify the cardiac phosphocreatine/ATP (PCr/ATP) ratio in SCH, compare with healthy controls (HC) and to measure the effect of 6 months of thyroxine treatment.Method: Cardia...